MEROPENEM, 500mg, powder, vial
Valid Article
MEROPENEM
Therapeutic Action
Antibacterial for systemic use, from carbapenem group
Broad spectrum antibiotic
Meropenem does not need to be combined with cilastatin, as it is metabolised through a different pathway.
Indications
Severe infections caused by Gram-positive and Gram-negative aerobic and anaerobic bacteria.
Complicated infections in children over 3 months of age.
Drug-Resistant Tuberculosis (DR-TB):
- in children under 15 years and
- if possible, in epileptic patients and/or those with TB meningitis.
Instructions for use
Reconstitute the 500 mg powder vial with 10 ml of water for injection to obtain a reconstituted solution at 50 mg/ml meropenem. For the 1 g powder vial, reconstitute with 20 ml of water for injection.
The reconstituted solution must be given as deep IV infusion:
- children < 20kg: in 5 ml/kg of 0.9% NaCl
- children and adults > 20 kg: in 100 ml of 0.9% NaCl
Administer clavulanic acid PO 60 minutes prior to each dose of meropenem to prevent carbapenem resistance.
Precautions for Use
May cause gastrointestinal disturbances, neurotoxicity and hypersensitivity reactions.
Storage
- Below 25ºC - Protect from sunlight
- After reconstitution, use the solution immediately.