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ENTECAVIR, 1mg, tab.

https://unicat.msf.org/cat/product/75344
STD DORAENTE1T-

Valid Article

6.4.4.1.1 - Nucleoside/Nucleotide reverse transcriptase inhibitors
Classification of the medicines in groups and subgroups according to their therapeutic use. The classification used by MSF is based on the WHO Model List of Essential Medicines.
J05AF10
Anatomical Therapeutic Chemical Classification according to WHOCC
PA
The order of this product needs to be justified and is only acceptable under certain conditions.
1525
Thermosensitive codes are defined for storage and transportation temperature requirements of the products.
OC subscriptions: included in supply or field order tools (e.g. UniField)
SC subscriptions: included in supply or field tools
OC validations: approved for procurement and use by an OC for international or local orders specifying context and activity in Medical Standard Lists (MSL)
https://www.unicat.msf.org/web/image/product.template/587066/image_1920?unique=6cd0bc2

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ENTECAVIR

Therapeutic Action

Antiretroviral, nucleotide reverse transcriptase inhibitor (NRTI)

Indications

Chronic hepatitis B virus (HBV) infection in adults, adolescents and children (aged two years and older) for whom antiviral therapy is indicated.

First-line treatment of HBV infection in adults with established osteoporosis and/or impaired kidney function.

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Instructions for use

The 0.5 mg dosage is intended for paediatric use.

In case of evidence of treatment failure due to confirmed or suspected antiviral resistance to entecavir or supply constraints, tenofovir disoproxil fumarate may be used as an alternative in adults and adolescents from 12 years of age.

Closely monitor:

  • liver function tests (ALT, AST)
  • HBV DNA levels to assess efficacy
  • signs of lactic acidosis or hepatotoxicity

Precautions for Use

Administer with caution in patients with renal impairment. Closely monitor renal function .

Most common side effects: headache, fatigue, dizziness, and nausea.

Spontaneous exacerbations in hepatitis are relatively common and are characterised by transient increases in serum ALT levels.

Storage

Below 25ºC - Protect from sunlight